Key result
Higher CAVI linked to ~80% greater odds of paroxysmal AF per unit increase.
Why the study?
Is increased arterial stiffness, measured by the cardio-ankle vascular index, associated with the presence of paroxysmal atrial fibrillation in outpatients?
Cross-Sectional (n=181)
Is increased arterial stiffness, measured by the cardio-ankle vascular index, associated with the presence of paroxysmal atrial fibrillation in outpatients?
Increased arterial stiffness, as measured by the cardio-ankle vascular index, is independently associated with the presence of paroxysmal atrial fibrillation.
May mark arterial stiffness as a paroxysmal AF correlate in outpatients; hypothesis-generating and requires prospective validation before any clinical use.
BACKGROUND: Several lines of evidence suggest that atrial fibrillation (AF) may be a consequence of vascular disease. We investigated the relationship between cardio-ankle vascular index (CAVI), a new index of arterial stiffness, and the presence of paroxysmal AF (PAF). METHODS AND RESULTS: 181 outpatients (91 patients with PAF and 90 age- and gender-matched subjects without PAF) were analysed for their sinus rhythm. The CAVI was significantly higher in patients with PAF than in subjects without PAF (9.0±1.0 vs 8.7±0.8, p<0.01). In all subjects, the CAVI was significantly correlated with the left ventricular mass index (r=0.30, p<0.01), left atrial diameter (r=0.22, p<0.01), and augmentation index, a parameter of wave reflection (r=0.32, p<0.01), in addition to age, systolic blood pressure and pulse pressure. Logistic analysis demonstrated that the CAVI was independently associated with PAF even after adjustment for confounding factors. The adjusted OR of PAF was 1.8 for each unit increase in the CAVI (p=0.01). CONCLUSIONS: Our finding suggests that increased arterial stiffness may be involved in the maintenance of AF.
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Miyoshi et al. (2014) conducted a cross-sectional in Paroxysmal atrial fibrillation (n=181). Cardio-ankle vascular index (CAVI) vs. Subjects without paroxysmal atrial fibrillation was evaluated on Presence of paroxysmal atrial fibrillation (OR 1.8, p=0.01). Increased arterial stiffness, measured by the cardio-ankle vascular index (CAVI), was independently associated with paroxysmal atrial fibrillation (adjusted OR 1.8 per unit increase; p=0.01).
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