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August 28, 2020Journal of Atherosclerosis and ThrombosisOpen Access

The Association of Cardio-Ankle Vascular Index (CAVI) with Biatrial Remodeling in Atrial Fibrillation

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Key result

Higher Cardio-Ankle Vascular Index (CAVI) was significantly correlated with increased left atrial volume index (r=0.297) and right atrial volume index (r=0.252), indicating a close association between arterial stiffness and biatrial remodeling in atrial fibrillation.

Why the study?

The impact of arterial stiffness on the process of atrial remodeling in association with AF had not been fully evaluated.

Does arterial stiffness measured by CAVI correlate with biatrial remodeling in patients with atrial fibrillation?

Population

213 analyzed patients with AF undergoing ablation

Comparison

Cardio-ankle vascular index levels

Design

Cross-sectional study

Authors

KNKeijiro NakamuraTTTakahito TakagiNKNorihiro Kogame

Discussion

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Member takes

Overview

Supports CAVI association with biatrial remodeling in AF; hypothesis-generating and requires prospective validation before clinical consideration.

Study Design

Type

Cross-Sectional (n=213)

Multicenter

No

Structured PICO

Does arterial stiffness measured by CAVI correlate with biatrial remodeling in patients with atrial fibrillation?

P
Population
213 patients (mean age 64.7 years, 27.4% female) with atrial fibrillation undergoing catheter ablation, evaluated cross-sectionally for the association between arterial stiffness and atrial remodeling.
E
Exposure
Cardio-ankle vascular index (CAVI) measurement as a marker of arterial stiffness
O
Outcome
Correlation of CAVI with atrial structural and electrical remodeling (LA and RA volumes by computed tomography, atrial conduction and voltage amplitude by 3D electromapping)surrogate

Main Result

Effect estimate: r = 0.297

p-value: p=0.001

Arterial stiffness, as measured by CAVI, is independently associated with structural and electrical biatrial remodeling in patients with atrial fibrillation.

Limitations

  • Single-center trial with relatively small sample size
  • Histological examination and atrial function were not examined with speckle-tracking echocardiography
  • Patients were relatively elderly and predominantly male, limiting generalizability
  • Cross-sectional design prevents drawing causal conclusions regarding the relationship between CAVI and biatrial remodeling

Cite This Study

Nakamura et al. (2020) conducted a cross-sectional in Atrial Fibrillation (n=213). Cardio-ankle vascular index (CAVI) vs. Lower/Normal CAVI was evaluated on Correlation between CAVI and left atrial volume index (LAVI) (r = 0.297, p=0.001). Higher Cardio-Ankle Vascular Index (CAVI) was significantly correlated with increased left atrial volume index (r=0.297) and right atrial volume index (r=0.252), indicating a close association between arterial stiffness and biatrial remodeling in atrial fibrillation.

synapsesocial.com/papers/6a21e5faecc82e5463b92bb9https://doi.org/10.5551/jat.57737
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardio-Ankle Vascular Index is a Candidate Predictor of Coronary Atherosclerosis2007 · 271 citations
  2. 2A Novel Blood Pressure-independent Arterial Wall Stiffness Parameter; Cardio-Ankle Vascular Index (CAVI)2006 · 949 citations
  3. 3Association of Cardio-Ankle Vascular Index with Brain Natriuretic Peptide Levels in Hypertension2011 · 24 citations
  4. 4Principles and usefulness of the cardio-ankle vascular index (CAVI): a new global arterial stiffness index2017 · 64 citations
  5. 5Coefficients in the CAVI Equation and the Comparison Between CAVI With and Without the Coefficients Using Clinical Data2018 · 56 citations