The effect of different immunosuppressive agents on survival of kidney grafts from BN to WAG inbred rat strains was studied. Animals given continuous treatment with nontoxic doses of Imuran showed a marked prolongation of survival time as compared with untreated controls. Some effect was seen from daily treatment with prednisolone and from repeated local irradiation of the graft. Kidney-transplantation in the rat appears to be a useful model for the study of immunosuppressive measures for clinical application.
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W. J. TINBERGEN (1968) studied this question.