Key result
Medical ICU admission for octogenarians is associated with ~76% higher long-term mortality versus younger patients.
Why the study?
Does age ≥80 years affect resource consumption and mortality in patients admitted to a medical ICU compared to younger patients?
Observational (n=6,662)
No
Does age ≥80 years affect resource consumption and mortality in patients admitted to a medical ICU compared to younger patients?
Hazard Ratio: 1.76 (95% CI 1.56–1.989)
p-value: p=<.001
Octogenarians admitted to the ICU have higher mortality and receive less invasive care than younger patients, but specific cardiac admission diagnoses are stronger predictors of long-term survival than age or severity scores.
Octogenarian ICU decisions warrant individualized assessment beyond age alone; leaves open whether specific cardiac diagnoses outweigh age in predicting survival.
The aging population increases the demand of intensive care unit (ICU) treatments. However, the availability of ICU beds is limited. Thus, ICU admission of octogenarians is considered controversial. The population above 80 years is a very heterogeneous group though, and age alone might not be the best predictor. Aim of this study was to analyze resource consumption and outcome of octogenarians admitted to a medical ICU to identify reliable survival predictors in a senescent society.This retrospective observational study analyzes 930 octogenarians and 5732 younger patients admitted to a medical ICU. Admission diagnosis, APACHE II and SAPS II scores, use of ICU resources, and mortality were recorded. Long-term mortality was analyzed using Kaplan-Meier survival curves and multivariate cox regression analysis.Patients ≥80 years old had higher SAPS II (43 vs 38, P < .001) and APACHE II (23 vs 21, P = .001) scores. Consumption of ICU resources by octogenarians was lower in terms of length of stay, mechanical ventilation, and renal replacement therapy. Among octogenarians, ICU survivors got less mechanical ventilation or renal replacement therapy than nonsurvivors. Intra-ICU mortality in the very old was higher (19% vs 12%, P < .001) and long-term survival was lower (HR 1.76, P < .001). Multivariate cox regression analysis of octogenarians revealed that admission diagnosis of myocardial infarction (HR 1.713, P = .023), age (1.08, P = .002), and SAPS II score (HR 1.02, 95%, P = .01) were independent risk factors, whereas admission diagnoses monitoring post coronary intervention (HR .253, P = .002) and cardiac arrhythmia (HR .534, P = .032) had a substantially reduced mortality risk.Octogenarians show a higher intra-ICU and long-term mortality than younger patients. Still, they show a considerable life expectancy after ICU admission even though they get less invasive care than younger patients. Furthermore, some admission diagnoses like myocardial infarction, cardiac arrhythmia and monitoring post cardiac intervention are much stronger predictors for long-term survival than age or SAPS II score in the very old.
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Muessig et al. (2017) conducted an observational in Medical Intensive Care Unit Admission (n=6,662). Age ≥80 years (Octogenarians) vs. Age <80 years was evaluated on Death of any cause (long-term mortality) (HR 1.76, 95% CI 1.560-1.989, p=<.001). Octogenarians admitted to a medical intensive care unit had a significantly higher long-term mortality risk compared to younger patients (HR 1.76), though they still demonstrated considerable life expectancy.
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