Key result
Neither standard heparin nor low molecular weight heparin demonstrated any evidence of passage across the placental barrier to the fetus.
Why the study?
Does unfragmented heparin or low molecular weight heparin pass the placental barrier to the fetus in pregnant women?
Population
36 pregnant women who had an abortion by hysterotomy between the 15th and 23rd week of pregnancy
Comparison
Unfragmented heparin or low molecular weight… vs No heparin (control group of 15 women)
Design
Cohort
Authors
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Supports mid-gestation heparin use without fetal exposure; leaves open confirmation at term or with chronic dosing.
Observational (n=36)
Does unfragmented heparin or low molecular weight heparin pass the placental barrier to the fetus in pregnant women?
Neither standard unfragmented heparin nor low molecular weight heparin crosses the placental barrier during the second trimester of pregnancy.
tzsch et al. (1991) conducted an observational in Pregnancy (n=36). Standard heparin or low molecular weight heparin (LMWH) vs. No heparin was evaluated on Transplacental passage of heparin to the foetus. Neither standard heparin nor low molecular weight heparin demonstrated any evidence of passage across the placental barrier to the fetus.
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