Key result
Hyperthyroidism treatment is linked to a ~65% reduction in hepatic lipase activity and higher HDL-cholesterol.
Why the study?
Does treatment of hyperthyroidism alter hepatic lipase activity and plasma lipoprotein concentrations in patients with hyperthyroidism?
Population
16 patients with hyperthyroidism
Comparison
Treatment for hyperthyroidism vs Baseline (before treatment)
Design
Cohort
Authors
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Treatment effects on hepatic lipase warrant no practice change yet; leaves open its role in HDL regulation during hyperthyroidism.
Observational (n=16)
Does treatment of hyperthyroidism alter hepatic lipase activity and plasma lipoprotein concentrations in patients with hyperthyroidism?
Treatment of hyperthyroidism decreases hepatic lipase activity, which correlates with an increase in HDL-cholesterol concentrations, suggesting hepatic lipase is an important determinant of plasma HDL levels.
Valdemarsson et al. (1984) conducted an observational in Hyperthyroidism (n=16). Treatment for hyperthyroidism vs. Baseline (before treatment) was evaluated on Hepatic lipase activity, lipoprotein lipase activity, and plasma lipoprotein concentrations. Treatment of hyperthyroidism significantly decreased hepatic lipase activity by 65%, which correlated with increased HDL-cholesterol concentrations (r=0.51, P<0.05).
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