Key result
Mid-twentieth century research identifies stress as a physiological mechanism driving heart disease development and progression.
Design
Review
Authors
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No immediate change to clinical stress assessment in CVD; leaves open rigorous modern validation of historical mechanisms.
This historical review outlines the mid-twentieth-century origins of the stress hypothesis in heart disease, driven by experimental work on homeostasis and the general adaptation syndrome.
Heather Rogers (2016) conducted a review in Heart disease. Stress was evaluated. Stress was hypothesized and experimentally supported in the mid-twentieth century as a physiological mechanism contributing to the development and progression of heart disease.
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