Key result
Intraoperative glucose-insulin-potassium administration during coronary artery bypass grafting resulted in a myocardial infarction rate of 4.2% compared to 13% in the control group, though results were inconclusive due to small sample size.
Why the study?
Does intraoperative Glucose-Insulin-Potassium improve myocardial protection and prevent perioperative myocardial infarction in patients undergoing coronary artery bypass surgery?
RCT (n=56)
Open-label
Randomized
No
Does intraoperative Glucose-Insulin-Potassium improve myocardial protection and prevent perioperative myocardial infarction in patients undergoing coronary artery bypass surgery?
Absolute Event Rate: 4.2% vs 13%
The text highlights the need for improved myocardial protection techniques during coronary artery bypass surgery to reduce the 10-20% incidence of perioperative myocardial infarction.
Myocardial Protection with GIK-HurlessA topic of interest to extracorporeal technologists and great practicality for patients having cardiac surgery is how best to protect the myocardium from ischemic injury during cardiopulmonary bypass.Two methods of protection-profound local myocardial hypothermia and maintenance of mean systemic arterial pressure at prebypass levels-have gained acceptance. 1 , 2 Cardiac surgery today in terms of mortality and morbidity has a proven record of safety.On the other hand, is cardiac surgery safe enough?We believe the answer is no.While survival after cardiac surgery is the rule, the published figures for peri operative myocardial infarction of 10 to 20%, occurring ironically during coronary artery by-pass operations done to prevent myocardial infarctions, demonstrate that technics for protecting the myocardium are imperfect.3 -14 Improved methods for protecting myocardial cells during all cardiac operations should be identified and put into practice.
No takes yet. Share an insight, caveat, or question.
Hurless et al. (1976) conducted an RCT in Coronary artery disease requiring myocardial revascularization (n=56). Glucose-Insulin-Potassium (GIK) vs. Normosol-R was evaluated on Myocardial infarction (defined as 24-hour CPK-MB isoenzyme ≥100 IU/l). Intraoperative glucose-insulin-potassium administration during coronary artery bypass grafting resulted in a myocardial infarction rate of 4.2% compared to 13% in the control group, though results were inconclusive due to small sample size.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: