Key result
Calcium-activated chloride channels may control the inverse correlation between intracellular calcium activity and renin secretion from renal juxtaglomerular epithelioid cells.
This paper hypothesizes that calcium-activated chloride channels may control renin secretion by regulating intracellular calcium activity in juxtaglomerular cells.
May link Ca-activated Cl channels to renin control via cell volume; leaves open therapeutic relevance in hypertension.
The rate of renin secretion from renal juxtaglomerular epithelioid cells appears to be inversely correlated to intracellular Ca activity. Such a dependency of renin secretion on Ca activity could be controlled by Ca-activated Cl channels that may be involved in the volume control of juxtaglomerular cells.
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Armin Kurtz (1990) studied this question. Calcium-activated chloride channels may control the inverse correlation between intracellular calcium activity and renin secretion from renal juxtaglomerular epithelioid cells.
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