Key result
Organic calcium channel antagonists only occasionally stimulate renin secretion, suggesting that other effects of these substances counteract their expected stimulatory effects.
Design
Review
Authors
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Does not support avoiding calcium channel antagonists over renin concerns; leaves open their net RAAS effects in practice.
The expected stimulation of renin secretion by calcium channel antagonists is often counteracted by other physiological effects of these substances.
Paul C. Churchill (2008) reported a review. Calcium channel antagonists was evaluated. Organic calcium channel antagonists only occasionally stimulate renin secretion, suggesting that other effects of these substances counteract their expected stimulatory effects.
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