Key result
Female sex linked to ~35% higher in-hospital mortality for ruptured AAA regardless of repair type.
Why the study?
Does female sex increase the risk of in-hospital mortality in adult patients hospitalized for ruptured abdominal aortic aneurysms compared to male sex?
Observational (n=75,698)
Yes
Does female sex increase the risk of in-hospital mortality in adult patients hospitalized for ruptured abdominal aortic aneurysms compared to male sex?
Odds Ratio: 1.35 (95% CI 1.24–1.47)
Absolute Event Rate: 53.5% vs 41.9%
p-value: p=<0.001
Despite overall decreasing trends in mortality for ruptured abdominal aortic aneurysms, females remain at a significantly higher risk of in-hospital death compared to males regardless of the surgical repair procedure.
May prompt heightened perioperative attention for females with ruptured abdominal aortic aneurysm; leaves open whether sex-specific strategies improve outcomes.
We sought to describe and analyze discrepancies between sexes in the outcomes of patients hospitalized for ruptured abdominal aortic aneurysms (rAAA) by conducting a retrospective analysis of the Nationwide Inpatient Sample. The review included all adult patients (≥18 years old) hospitalized with a primary diagnosis of rAAA between January 2002 and December 2014. In-hospital mortality differences between females and males were analyzed overall and separately among those receiving endovascular AAA repair (EVAR) or open AAA repair (OAR). In-hospital mortality for females declined from 61.0% in 2002 to 49.0% in 2014 (P for trend <0.001), while mortality for males declined from 48.6% in 2002 to 32.2% in 2014 (P for trend <0.001). Among those receiving EVAR, females were significantly more likely to die in the hospital than males (adjusted odds ratio [OR], 1.44; 95% CI, 1.12-1.84). In addition, the odds of mortality among those receiving OAR were higher for females than males (adjusted OR, 1.14; 95% CI: 1.00-1.31). These data provide evidence that despite overall decreasing trends in mortality for both sexes, females remain at higher risk of death compared with males regardless of surgical repair procedure.
No takes yet. Share an insight, caveat, or question.
Stuntz et al. (2017) conducted an observational in Ruptured abdominal aortic aneurysm (n=75,698). Female sex vs. Male sex was evaluated on In-hospital mortality (OR 1.35, 95% CI 1.24-1.47, p=<0.001). Female patients hospitalized for ruptured abdominal aortic aneurysm had significantly higher adjusted odds of in-hospital mortality compared to males (OR 1.35), a disparity that persisted regardless of surgical repair type.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: