Key result
Non-invasive ventilation fails to reduce 7-day mortality versus standard oxygen in acute cardiogenic pulmonary edema.
Design
Review
Authors
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Does not support routine non-invasive ventilation for mortality reduction in acute cardiogenic pulmonary oedema; leaves open effects on intubation or symptoms.
RCT (n=1,069)
randomized
Yes
Absolute Event Rate: 9.5% vs 9.8%
p-value: p=0.87
This report provides a summary of key clinical trials presented at the 2007 European Society of Cardiology Congress spanning heart failure, electrophysiology, prevention, and interventional cardiology.
Zegers et al. (2007) conducted an RCT in acute cardiogenic pulmonary oedema (n=1,069). Non-invasive ventilation (CPAP or NIPPV) vs. Standard oxygen therapy was evaluated on 7-day mortality (p=0.87). Non-invasive ventilation did not significantly reduce 7-day mortality compared to standard oxygen therapy in patients with acute cardiogenic pulmonary oedema (9.5% vs. 9.8%; P=0.87).
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