Key result
Patients with ischemic heart disease combined with chronic obstructive pulmonary disease exhibit distinct chronic heart failure phenotypes, including preserved ejection fraction with or without right ventricular dysfunction, and reduced ejection fraction with biventricular failure.
Observational (n=320)
No
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Identified distinct phenotypes of heart failure in patients with ischemic heart disease and COPD, providing a pathophysiologic basis for targeted pharmacotherapy.
The aim of this study: on the basis of clinical and instrumental complex investigation of 320 patients with chronic heart failure (CHF) of ischemic etiology combined with chronic obstructive pulmonary disease (COPD) it was proposed to identify several phenotypes of including CHF with preserved ejection fraction (CHFpEF) without right ventricular dysfunction (RVD); CHFpEF with RVD; CHFpEF with right-side failure (RSF); CHF with reduced EF (CHFrEF) plus RSF (biventricular). Identification of these phenotypes creates the pathophysiologic basis to development of rathional pharmacotherapy of CHF in patients with ischemic heart disease combined with COPD.
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V. A. Potabashniy (2018) conducted an observational in Chronic heart failure with ischemic heart disease and chronic obstructive pulmonary disease (n=320). Ischemic heart disease combined with chronic obstructive pulmonary disease vs. Healthy controls and patients without CHF was evaluated on Echocardiographic structural and functional parameters of the left and right ventricles. Patients with ischemic heart disease combined with chronic obstructive pulmonary disease exhibit distinct chronic heart failure phenotypes, including preserved ejection fraction with or without right ventricular dysfunction, and reduced ejection fraction with biventricular failure.
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