Key result
In children at high risk of developing acute rheumatic fever, the pooled incidence of sore throat was 82.5 per 100 child-years and the incidence of group A streptococcal pharyngitis was 10.8 per 100 child-years.
Why the study?
While GAS pharyngitis has traditionally been considered the sole precursor of ARF, evidence suggests GAS skin infections may contribute, leaving the incidence of sore throat and GAS pharyngitis in this setting as a missing piece of evidence.
Population
Children at risk of ARF across 11 included articles
Design
Systematic review and meta-analysis
Authors
Loading...
High pharyngitis burden in at-risk children warrants targeted surveillance; extends pooled incidence estimates for ARF prevention trial design.
Systematic Review (n=16,814)
Effect estimate: 82.5 per 100 child-years (95% CI 6.5-1044.4)
The incidence of sore throat in children at risk for acute rheumatic fever is higher than in developed nations, while GAS pharyngitis rates are similar, highlighting the need for further studies to inform primary prevention strategies for rheumatic heart disease.
Pearce et al. (2020) conducted a systematic review in High risk of acute rheumatic fever (n=16,814). High risk of acute rheumatic fever was evaluated on Incidence of sore throat (82.5 per 100 child-years, 95% CI 6.5-1044.4). In children at high risk of developing acute rheumatic fever, the pooled incidence of sore throat was 82.5 per 100 child-years and the incidence of group A streptococcal pharyngitis was 10.8 per 100 child-years.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: