A 23-year-old man had epidermolysis bullosa acquisita that was diagnosed at the age of 20 years. The eye examination showed bilateral, small subepithelial vesicles in the cornea. The direct immunofluorescence microscopic examination of the conjunctiva revealed homogeneous, linear IgG and fibrinogen deposits in the basement membrane area. The same pattern appeared in the skin biopsy specimen. No systemic disease common to epidermolysis bullosa acquisita was found in the patient.
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Manfred Zierhut (1989) studied this question.
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