Key result
Nicotinic acid treatment increased mean plasma free fatty acid levels compared to baseline in patients with hyperlipemia, despite reducing plasma triglycerides and cholesterol.
Why the study?
Does nicotinic acid treatment affect diurnal variations of plasma free fatty acids in patients with hyperlipemia?
Does nicotinic acid treatment affect diurnal variations of plasma free fatty acids in patients with hyperlipemia?
Nicotinic acid treatment increases mean plasma FFA levels, challenging the hypothesis that its lipid-lowering effect is secondary to inhibition of FFA mobilization from adipose tissue.
Authors
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Challenges mechanistic assumptions for nicotinic acid in hyperlipemia; hypothesis-generating from Level 5 evidence and should not change practice.
Carlström et al. (1968) studied Hyperlipemia (n=4). Nicotinic acid vs. Before treatment (baseline) was evaluated on Diurnal variations of plasma free fatty acids (FFA). Nicotinic acid treatment increased mean plasma free fatty acid levels compared to baseline in patients with hyperlipemia, despite reducing plasma triglycerides and cholesterol.
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