Integrative neuroscience in traumatic brain injury: Multimodal imaging, network models, and precision medicine

Traumatic brain injury (TBI) is a major global health challenge, with growing recognition of its complexity across diverse contexts.The heterogeneity of TBI, in its presentation, mechanisms, and recovery trajectories, calls for sophisticated neuroimaging approaches to adequately capture its multifaceted nature (Covington and Duff, 2021).Ample functional and structural neuroimaging studies of TBI (e.g., Imms et al., 2024Imms et al., , 2023;;Clemente et al., 2023;Mahoney et al., 2022;Shida et al., 2023) reveal diffuse axonal injuries, white matter disruption, widespread morphological alterations and altered functional connectivity.This Special Issue presents a collection of research using innovative methods to capture the manifold range of neurological alterations post-TBI.Emerging methodological approaches that integrate information across neuroimaging modalities and harness multidisciplinary metrics are highlighted.