Prevention of Pernicious Anemia: Recognition of the Latent Stage in Relatives

Article1 October 1940PREVENTION OF PERNICIOUS ANEMIA: RECOGNITION OF THE LATENT STAGE IN RELATIVESJOHN MARTIN ASKEY, F.A.C.P.JOHN MARTIN ASKEY, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-4-593 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe diagnosis of Addisonian pernicious anemia ordinarily is made over a year after symptoms have been definitely established.1 About 75 per cent of patients with this disease have involvement of the nervous system,2, 3 and this condition is often recognized too late to prevent partially disabling nervous system lesions. The deaths attributable to pernicious anemia are due largely to complications of these lesions. Treatment may prevent further progress but cannot correct irreparable spinal cord damage.The challenge for the future must be to diagnose pernicious anemia before the appearance of blood and nervous system changes. This will inaugurate an era...Bibliography1. MINOT GR: Some aspects of the diagnosis of pernicious anemia, Med. Clin. N. Am., 1935, xviii, 935-944. Google Scholar2. SMITHBURNZERFAS KCLG: Neural symptoms and signs in pernicious anemia; effects of liver extract, Arch. Neurol. and Psychiat., 1931, xxv, 1100-1110. CrossrefGoogle Scholar3. BAKERBORDLEYLONGCOPE BMJWT: Effect of liver therapy on neurologic manifestations of pernicious anemia, Am. Jr. Med. Sci., 1932, clxxxiv, 1-24. Google Scholar4. MEULENGRACHT E: Heredity factor in pernicious anemia, Am. Jr. Med. Sci., 1925, clxix, 177-195. Google Scholar5. MACKLIN MT: Role of heredity in disease, Medicine, 1935, xiv, 1-75. CrossrefGoogle Scholar6. 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CASTLE, M.D., F.A.C.P.Diabets mellitus and pernicious anemiaThe deficiency anemiasPernicious Anemia * 1 October 1940Volume 14, Issue 4Page: 593-607KeywordsBloodForecastingLesionsNervous systemPernicious anemiaSpinal cord Issue Published: 1 October 1940 PDF downloadLoading ...