Key result
Fatal metastatic angiosarcoma presents as recurrent popliteal aneurysm hemorrhage with refractory bleeding.
Why the study?
Angiosarcoma is a rare and aggressive vascular tumor with high potential for misdiagnosis, presenting diagnostic and therapeutic challenges.
Case Report (n=1)
No
This case underscores the importance of considering angiosarcoma in unusual cases of aneurysmal hemorrhage.
May warrant considering angiosarcoma in refractory popliteal aneurysm hemorrhage; leaves open whether it alters diagnostic evaluation.
BACKGROUND: Angiosarcoma is a rare and aggressive vascular tumor that often presents diagnostic and therapeutic challenges. Its potential for misdiagnosis emphasizes the importance of a multidisciplinary approach. CASE SUMMARY: A 54-year-old man with Loeys-Dietz syndrome and a history of popliteal artery aneurysm treated with surgical exclusion and autologous vein bypass presented with a recurrent hemorrhage from the popliteal fossa. Despite repeated surgical resection and embolization, persistent bleeding led to diffuse alveolar hemorrhage and respiratory failure. Autopsy confirmed metastatic angiosarcoma with bilateral lung involvement. DISCUSSION: Angiosarcoma is often misdiagnosed due to nonspecific symptoms and overlapping features with benign vascular conditions. This report highlights the rarity, aggressive nature, metastatic potential, and clinically intricate management of popliteal angiosarcoma. TAKE-HOME MESSAGE: This case underscores the importance of considering angiosarcoma in unusual cases of aneurysmal hemorrhage and the need for comprehensive pathology and a multidisciplinary approach for early detection and treatment.
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Fereydooni et al. (2025) conducted a case report in Angiosarcoma (n=1). Surgical resection and embolization was evaluated on Clinical outcome. A 54-year-old man with recurrent popliteal aneurysm hemorrhage was diagnosed with metastatic angiosarcoma at autopsy after refractory bleeding and respiratory failure.
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