Key result
Diabetes duration over a decade linked to ~228% higher microangiopathy odds in adult diabetic outpatients.
Why the study?
Few data were available on diabetic microangiopathy in Madagascar.
Cross-Sectional (n=100)
No
Diabetic microangiopathy is highly prevalent (62%) among type 2 diabetic outpatients in Madagascar, strongly associated with longer disease duration, abdominal obesity, and poor glycemic control.
Answers are grounded in this paper and cite their sources.
High prevalence supports targeted microangiopathy screening in type 2 diabetes; leaves open causality and generalizability beyond this cross-sectional cohort.
Background: The microvascular complications of diabetes correspond to diabetic microangiopathy including retinopathy, nephropathy and neuropathy. Few data are available on diabetic microangiopathy in Madagascar. The aims of the present study were to determine the prevalence of microangiopathy and their associated factors in a population of type 2 diabetics seen as outpatients in the Endocrinology Department of Joseph Raseta Befelatanana Hospital, in Antananarivo, Madagascar. Methods: Cross-sectional, descriptive and analytical study was conducted over a 6-month period. Retinopathy was diagnosed by specific abnormalities on fundus examination, nephropathy by albuminuria ≥30 mg/24h, and peripheral neuropathy by symmetrical distal sensory symptoms beginning in the lower limbs, a DN4 score ≥4/10 and/or impaired foot sensitivity. Results: Of the one hundred type 2 diabetics included in the study, sixty-two (62%) had presented with one or more diabetic microangiopathy. Associated factors were diabetes duration ≥10 years (OR=3.28; 95% CI: 1.17-9.22), abdominal obesity (OR=1.72; 95% CI: 1.06-2.77) and HbA1c >10% (OR=3.72; 95% CI: 1.02-13.48). Albuminuria was significantly higher in type 2 diabetics with microangiopathy than in without (p<0.01) while estimated glomerular function rate was significantly lower (p=0.04). Conclusions: Diabetic microangiopathy was frequent. Optimal management of hyperglycemia, obesity and associated cardiovascular risk factors is essential to avoid or limit their occurrence.
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Raherison et al. (2025) conducted a cross-sectional in Type 2 diabetes (n=100). Diabetes duration ≥10 years vs. Diabetes duration <10 years was evaluated on Presence of one or more diabetic microangiopathy (OR 3.28, 95% CI 1.17-9.22). Diabetic microangiopathy was present in 62% of type 2 diabetic outpatients and was associated with diabetes duration ≥10 years (OR 3.28), abdominal obesity (OR 1.72), and HbA1c >10% (OR 3.72).
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