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February 15, 1999Nucleic Acids ResearchOpen Access

Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs

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GMGiovanni MagaIstituto di Genetica Molecolare

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Giovanni Maga (1999) studied this question.

synapsesocial.com/papers/6aa24a892d2c45bea509625bhttps://doi.org/10.1093/nar/27.4.972
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro1994 · 133 citations
  2. 2High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase1993 · 319 citations