Key result
Intrapleural administration of 30 mg doxorubicin induced a radiation-recall phenomenon characterized by fever, dyspnoea, erythema, and pneumonitis in a 67-year-old woman.
Case Report (n=1)
Intrapleural administration of doxorubicin can trigger a radiation-recall pneumonitis in patients with prior thoracic radiotherapy.
Radiation-recall pneumonitis may follow intrapleural doxorubicin after prior radiotherapy; single case leaves open incidence and risk factors.
A 67-year-old woman developed a malignant pleural effusion 18 months after radical mastectomy and radiotherapy for carcinoma of the breast. After drainage, 30 mg of doxorubicin was instilled into the pleural cavity. Thirty-six hours later, she developed fever, dyspnoea, and erythema in the area of the previous radiotherapy field; patchy intrapulmonary opacities were evident on chest X-ray film. These features resolved over two weeks after treatment with prednisone and frusemide. We believe that this represents a radiation-recall phenomenon.
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Hill et al. (1983) conducted a case report in Malignant pleural effusion (n=1). Intrapleural doxorubicin was evaluated on Radiation-recall phenomenon. Intrapleural administration of 30 mg doxorubicin induced a radiation-recall phenomenon characterized by fever, dyspnoea, erythema, and pneumonitis in a 67-year-old woman.
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