The amastigote form of Leishmania mexicana parasites colonizes macrophage phagolysosomes and induces the enlargement of these compartments to form huge parasitophorous vacuoles. We report here that a purified secreted amastigote product, proteophosphoglycan, is a macromolecule which causes vacuolization of peritoneal macrophages in vitro. Secretion of this glycoconjugate by intracellular parasites may contribute to the expansion of phagolysosomal compartments in infected cells.
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Peters et al. (1997) studied this question.
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