Key result
The percentage of massive fatal pulmonary embolism cases among autopsies fell from 9.3% in the first five years to 3.8% in the last five years of the 15-year study period.
Population
6,858 deceased hospital and surgical patients in a university hospital from 1966 through 1980.
Design
Cohort
Follow-up
15 years (1966-1980)
Authors
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Decline in fatal PE at autopsy was associated with rising anticoagulant use; leaves open whether modern prophylaxis further reduces risk.
Observational (n=6,858)
No
Absolute Event Rate: 3.8% vs 9.3%
Hospital mortality from massive pulmonary embolism decreased significantly from 1966 to 1980, temporally associated with increased use of anticoagulants.
S. Edwards Dismuke (1986) conducted an observational in Pulmonary embolism (n=6,858). Time period (last 5 years vs first 5 years) vs. First five years (1966-1970) was evaluated on Massive fatal pulmonary embolism among autopsies. The percentage of massive fatal pulmonary embolism cases among autopsies fell from 9.3% in the first five years to 3.8% in the last five years of the 15-year study period.
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