Key result
In 40 patients with persistent atrial fibrillation, higher myocardial expression of SERCA2a and CASQ2 correlated with larger left atrial size, higher ventricular volumes, and lower diastolic filling rates.
Why the study?
The study evaluated the relationship between myocardial expression of SERCA2a and CASQ2 and structural and functional heart characteristics in patients with permanent atrial fibrillation.
Observational (n=40)
Expression levels of calcium handling proteins SERCA2a and CASQ2 in the left ventricle correlate with structural and functional echocardiographic parameters in patients with permanent atrial fibrillation.
Correlations between SERCA2a/CASQ2 expression and adverse remodeling in persistent AF are hypothesis-generating; leaves open causal and therapeutic implications.
The relationship between the expression level of Ca2+-ATPase (SERCA2a) and calsequestrin (CASQ2) and the structural and functional characteristics of the heart of patients with permanent atrial fibrillation was studied. The study included 40 patients with persistent atrial fibrillation. Patients underwent radiofrequency ablation (RFA), during which a biopsy of myocardial tissue was taken from the left ventricle. Intracardiac hemodynamic parameters were recorded from standard echocardiographic positions. The content of SERCA2a and CASQ2 proteins in the myocardium was determined by immunoblotting. Correlation was found between the level of SERCA2a and CASQ2 in the myocardium and the size of the left atrium. Patients with higher values of end-diastolic and end-systolic heart volumes had high levels of SERCA2a. Lower rates of early (peak E) and late (peak A) diastolic filling of the left ventricle were associated with high SERCA2a expression. The level of expression of the calcium handling proteins Ca2+-ATPase and calsequestrin was associated with the structural and functional parameters of the heart of patients with permanent atrial fibrillation.
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Kondratieva et al. (2021) conducted an observational in Permanent atrial fibrillation (n=40). Expression levels of SERCA2a and CASQ2 was evaluated on Structural and functional parameters of the heart (left atrial size, end-diastolic/systolic volumes, diastolic filling). In 40 patients with persistent atrial fibrillation, higher myocardial expression of SERCA2a and CASQ2 correlated with larger left atrial size, higher ventricular volumes, and lower diastolic filling rates.
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