What question did this study set out to answer?

To determine the long-term impact of oral nicotine consumption on age-associated motor decline, organ pathology, and systemic metabolic homeostasis.

July 28, 2025Advanced ScienceOpen Access

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

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Authors

SJShuhui JiaShenzhen Institutes of Advanced Technology XJXiaoyuan JingWuhan University RWRuoxi WangShenzhen Institutes of Advanced Technology

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Implication

Animal study reveals oral nicotine preserves motor function and reprograms sphingolipid metabolism in aging mice, suggesting systemic lipid homeostasis promotes healthy aging.

Key Points

To determine the long-term impact of oral nicotine consumption on age-associated motor decline, organ pathology, and systemic metabolic homeostasis.
Allowed mice to orally consume nicotine for 22 months until reaching 24 months of age.
Performed multi-organ metabolomics, series expression miner-based longitudinal gut microbiota profiling, and in vitro validation in C2C12 cells.
Long-term nicotine consumption attenuated age-related motor decline without triggering immune dysfunction or pathological changes in major metabolic organs, yielding a younger Behavior-Metabolome Age score.
Nicotine altered the gut microbiome and regulated sphingolipid turnover via sphingomyelin synthases and neutral sphingomyelinases, elevating nicotinamide adenine dinucleotide availability and reducing ceramide accumulation.

Cite This Study

Jia et al. (2025) studied this question.

synapsesocial.com/papers/6aa251d2f92980b6ef322e07 https://doi.org/10.1002/advs.202415311

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Implication

Animal study reveals oral nicotine preserves motor function and reprograms sphingolipid metabolism in aging mice, suggesting systemic lipid homeostasis promotes healthy aging.

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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