The ethanol extract of heartwood of Caesalpinia sappan. Linn (Caesalpiniceae) and three crude fractions [petroleum ether (60–80°C), diethyl ether, and ethyl acetate] were subjected to preliminary qualitative chemical investigation. The ethanol extract and its fractions underwent pharmacological screening for analgesic activity by using acetic acid-induced writhing in albino mice. The ethanol extract and its different fractions of heartwood of Caesalpinia sappan. exhibited significant analgesic activity (p < 0.01). In conclusion, the ethanol extract of heartwood of Caesalpinia sappan. and its three different crude fractions were found to show peripheral analgesic activity.
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Kiran et al. (2007) studied this question.
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