Key result
Systolic blood pressure loads were significantly associated with target organ damage, including increased pulse wave velocity, augmentation index, and carotid intima-media thickness in children.
Why the study?
Is daytime systolic blood pressure load an important risk factor for target organ damage in pediatric hypertension?
Observational (n=82)
Is daytime systolic blood pressure load an important risk factor for target organ damage in pediatric hypertension?
In pediatric hypertension, daytime systolic blood pressure load is significantly associated with target organ damage, highlighting the importance of ambulatory blood pressure monitoring for risk stratification.
ABPM-defined hypertension subtypes may associate with target organ damage in children; leaves open prospective validation before guiding care.
The aim of this study was to compare ambulatory blood pressure (BP) monitoring (ABPM) data and determine which hypertension type is a risk factor in target organ damage. A total of 82 children (47 boys) with suspected hypertension based on office BP measurements and considered hypertensive by ABPM were studied. Target organ damage included the following: 35.3% hypertensive retinopathy, 25.6% microalbuminuria, 15.8% increased left ventricular mass index, 29.2% increased carotid intima-media thickness (cIMT), 24.3% high augmentation index (AIx), and 19.5% high pulse wave velocity (PWV). The association between BP load, PWV, and cIMT was statistically significant. There were significant correlations between daytime systolic BP load, PWV, AIx, and cIMT. A statistically significant difference was also detected between nighttime systolic BP load, PWV, and cIMT values and nighttime diastolic BP load levels and values of AIx and cIMT. There was also a statistically significant difference between the high level of nighttime diastolic BP load and cIMT. The authors found that target organ damage was seen more often in children with primary hypertension who had systolic loads.
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Çonkar et al. (2015) conducted an observational in Pediatric Hypertension (n=82). Systolic blood pressure load was evaluated on Target organ damage (including hypertensive retinopathy, microalbuminuria, increased LVMI, increased cIMT, high AIx, and high PWV). Systolic blood pressure loads were significantly associated with target organ damage, including increased pulse wave velocity, augmentation index, and carotid intima-media thickness in children.
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