Key result
Taking ramipril at bedtime may account for the greater risk reduction for stroke and cardiovascular endpoints in the HOPE study than could be explained by blood pressure reduction alone.
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The timing of ramipril administration (at bedtime) is proposed as the explanation for the significant cardiovascular risk reduction despite small measured blood pressure reductions in the HOPE study.
R.W. Taylor (2003) reported a letter. Ramipril taken at bedtime was evaluated. Taking ramipril at bedtime may account for the greater risk reduction for stroke and cardiovascular endpoints in the HOPE study than could be explained by blood pressure reduction alone.
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