Amegakaryocytic Thrombocytopenia and an Analgesic

Letters and Corrections1 December 1981Amegakaryocytic Thrombocytopenia and an AnalgesicJ. FONT, M.D., B. NOMDEDEU, M.D., F. MARTINEZ-OROZCO, M.D., M. INGELMO, M.D., A. BALCELLS, M.D.J. FONT, M.D.Search for more papers by this author, B. NOMDEDEU, M.D.Search for more papers by this author, F. MARTINEZ-OROZCO, M.D.Search for more papers by this author, M. INGELMO, M.D.Search for more papers by this author, A. BALCELLS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-6-783_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Thrombocytopenia with decreased marrow megakaryoctyes as a pure hematologic syndrome is a rare clinical event that has been the subject of an article in your journal (1). The authors state that the differential diagnosis of this syndrome includes hereditary and acquired aplastic anemia, preleukemia, and systemic lupus erythematosus. We describe a patient with reversible drug-related thromocytopenia showing selective absence of marrow megakaryocytes.An 80-year-old white man had several costal fractures as a result of thoracic traumatism. As an analgesic a commercial combination of oxyphenbutazone and acetaminophen (paracetamol) was prescribed. The patient received it continously for 20 days...References1. STOLL D, BLUM S, PASQUALE D, and MURPHY S. Thrombocytopenia with decreased megakaryocytes: evaluation and prognosis. Ann Intern Med. 1981;94:170-5. LinkGoogle Scholar2. ARMSTRONG F and SCHERBEL A. Review of toxicity of oxyphenbutazone: report of a case of thrombocytopenic purpura. JAMA. 1961.175:614-5. CrossrefMedlineGoogle Scholar3. HEADING R. Purpura and paracetamol. Br Med J. 1968;3:743-4. CrossrefMedlineGoogle Scholar4. MIESCHER P and GRAF J. Drug-induced thrombocytopenia. Clin Haematol. 1980;9:505-19. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. FONT, M.D.; B. NOMDEDEU, M.D.; F. MARTINEZ-OROZCO, M.D.; M. INGELMO, M.D.; A. BALCELLS, M.D.Affiliations: Hospital Clinico Barcelona Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcquired amegakaryocytic thrombocytopenic purpura: Review of a not very well-defined disorderHuman megakaryocytic progenitor cellsAplastic anemia occurring as amegakaryocytic thrombocytopenia with and without an inhibitor of granulopoiesis 1 December 1981Volume 95, Issue 6Page: 783-783KeywordsAnalgesicsAplastic anemiaBone marrowDrugsLupus erythematosusMegakaryocytes ePublished: 1 December 2008 Issue Published: 1 December 1981 PDF downloadLoading ...