Purpura and paracetamol.

A positive personal or family-history of migraine, and had E.E.G.s which showed more ,abnormalities suggestive of latent migraine than those of controls on oral contraceptives who were headache-free.Moreover, these abnormalities persisted in those who had repeat E.E.G.s after discontinuing the pill, which suggests that the vascular abnormalities pre-existed.'In view of Dr. Grant's finding of prominent arterioles in 16% of pre-treaunent endonmetrial biopsies, it would seem reasonable to postulate a widespread vascular hyperreactivity, which frequently manifests as headache on oral contraceptives.My findings do not show the same specificity of response to the particular oestrogen/progesterone combination as do Dr.Grant's.In my series, the incidence of severe headache on Anovlar (norethisterone acetate, ethinyloestradiol) was 3.20/ (com- pared with Dr. Grant's 40%); 1.7% with Lyndiol (lynoestrenol, mestranol) (Dr.Grant 32%) and 6.2% with Ovulen (ethyn- odiol acetate, mestranol) (Dr.Grant 13'/).Moreover, headaches frequently persisted despite changing to another brand with a different combination once (23 %), twice (15°,), three or more times (7%) in an effort to overcome the headaches.-Iam, etc., Cheam,