Tissue Doppler examination of horses with left side cardiac valve insufficieny receiving ACE-inhibitor therapy

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Aortic and/or mitral valve insufficiency (n=29). Intervention: Enalapril vs. Baseline (pre-treatment). Primary outcome: Aortic dimension in horses with aortic valve insufficiency and dilatation (MD 0.40 cm, p=0.047).

H Gehlen; Martin Rapp

doi:10.21836/pem20180201

January 1, 2018Pferdeheilkunde Equine MedicineOpen Access

Tissue Doppler examination of horses with left side cardiac valve insufficieny receiving ACE-inhibitor therapy

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Why the study?

Does enalapril improve echocardiographic parameters in horses with left-sided cardiac valve insufficiency?

Study Design

Type

Observational (n=29)

Multicenter

No

Structured PICO

Does enalapril improve echocardiographic parameters in horses with left-sided cardiac valve insufficiency?

P

Population

29 horses (mean age 17 years) with aortic and/or mitral valve insufficiency, treated with enalapril and followed for 3 months.

I

Intervention

Enalapril 0.5 mg/kg body weight orally once daily for 3 months

C

Comparator

Intra-individual control (a subset of horses was examined 3 months prior to starting medication to assess disease progression without treatment)

O

Outcome

Echocardiographic parameters including conventional dimensions, fractional shortening, tissue Doppler velocities, and speckle tracking strain/strain ratesurrogate

Main Result

Mean Difference: 0.4

Absolute Event Rate: 6.37% vs 6.77%

p-value: p=0.047

Limitations

High variance in speckle tracking measurements
Small sample size
Lack of oral bioavailability data
High variance of measurements
Inconsistent and contradictory results between groups
Short treatment duration

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Implication

Enalapril therapy in horses with left-sided valve insufficiency showed mixed and inconsistent echocardiographic effects, highlighting the need for further studies with larger cohorts and longer follow-up.

Abstract

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Discussion

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Cite This Study

Gehlen et al. (2018) conducted an observational in Aortic and/or mitral valve insufficiency (n=29). Enalapril vs. Baseline (pre-treatment) was evaluated on Aortic dimension in horses with aortic valve insufficiency and dilatation (MD 0.40 cm, p=0.047).

synapsesocial.com/papers/6aa25cca03729a132ba58028 https://doi.org/10.21836/pem20180201

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Tissue Doppler examination of horses with left side cardiac valve insufficieny receiving ACE-inhibitor therapy

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Tissue Doppler examination of horses with left side cardiac valve insufficieny receiving ACE-inhibitor therapy

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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