Key result
Open-heart surgery in active cancer patients shows ~25% five-year survival.
Why the study?
Active cancer and heart disease can occur concomitantly, and open heart surgery may be required, motivating an evaluation of early and long-term results and intervention strategies in these patients.
Observational (n=10)
No
Open-heart surgery is feasible in patients with active malignancies and severe cardiac disease, offering acceptable early outcomes despite poor long-term survival driven by the underlying cancer.
Acceptable early outcomes support feasibility in select active-cancer cases; hypothesis-generating and should not yet change practice.
Introduction: Active cancer and heart disease, which share similar environmental and biological characteristics, can occur concomitantly. Open heart surgery may be required for these patients when indicated. This study aims to demonstrate the early and long-term results and discuss the intervention strategy in patients with different types of active malignancies, who underwent open-heart surgery. Patients and Methods: Between January 2012 and May 2020, open-heart surgery was performed on 10 patients with active malignancies. The mean age was 65.5 (52-77), and four of the patients were female. Two patients were operated on urgently due to advanced pleural effusion. AVR+CABG, CABG, CABG+left upper lobectomy, and AVR+MVR were performed in four patients with lung cancer; AVR+CABG were performed in one patient with colon cancer; CABG was performed in four patients each with one of the following conditions: lymphoma, breast cancer, essential thrombocytosis, meningioma); and mass resection operation from the left atrium and left ventricle was performed in one patient with osteosarcoma. Results: Eight patients were discharged and two patients died in the early postoperative period. Postoperative left hemiparesis developed in one patient. Six-month, one-year and five-year survival rates were 79%, 37.5% and 25%, respectively. Conclusion: Open-heart surgery can be successfully performed with acceptable mortality and morbidity rates on the high-risk patient group with active cancer.
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Toker et al. (2021) conducted an observational in Active oncological diseases and concurrent heart disease (n=10). Open-heart surgery was evaluated on Survival rates at 6 months, 1 year, and 5 years. Open-heart surgery in patients with active cancer resulted in 6-month, 1-year, and 5-year survival rates of 79%, 37.5%, and 25%, respectively, with two early postoperative deaths.
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