Microfluidic Bandage based on Diffusion Delivery

Over 400,000 people worldwide are living with Hemophilia A, a disease predominantly caused by deficiency of clotting factor VIII in the blood plasma.A localized application of the recombinant clotting factor VIII by integration with the contemporary bandage would help mitigate the damage caused by injuries in a hemophilia patient.The designed bandage would work on the principle of microfluidic diffusion delivery using a layer of membrane above which a microfluidic channel is present.The device was designed using a) Kinetic studies; b) Membrane Analysis; c) Finite element method.Hence an optimum design was achieved which provided maximum diffusion for minimum flow.The ease of application and the cheap manufacturing cost of the appliance, facilitates the large-scale production of this device at a low cost.This technique could further be extended to all drug delivery practices.