Key result
Statin therapy fails to achieve LDL targets in most high-risk patients while overtreating low-risk groups.
Why the study?
Does statin therapy achieve guideline-recommended LDL cholesterol targets in patients with primary hypercholesterolemia in real-world clinical practice?
Observational (n=52,848)
Yes
Does statin therapy achieve guideline-recommended LDL cholesterol targets in patients with primary hypercholesterolemia in real-world clinical practice?
In real-world clinical practice, the vast majority of high-risk patients starting statin therapy fail to achieve guideline-recommended LDL cholesterol targets, while overtreatment of low-risk patients is common.
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Reveals misalignment of statin use with risk-based LDL targets in practice; leaves open whether targeted interventions improve goal attainment.
Assmann et al. (2006) conducted an observational in primary hypercholesterolemia (n=52,848). Statin therapy was evaluated on Achievement of LDL cholesterol target of 2.6 mmol/l or below. Statin therapy failed to achieve LDL targets in most high-risk patients after 9 months (only 8.0% of high-risk men and 6.2% of high-risk women), while overtreatment of low-risk groups was common.
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