Key result
Norepinephrine agonism dramatically improves symptoms in a patient with non-parkinsonian neurogenic orthostatic hypotension.
Why the study?
Accurate diagnosis and management of neurogenic orthostatic hypotension is important especially when conservative measures fail, and it typically presents with Parkinson disease or Parkinson plus syndromes.
Case Report (n=1)
Norepinephrine agonism can be an effective treatment for neurogenic orthostatic hypotension even in the absence of parkinsonian features.
May extend norepinephrine agonism to atypical neurogenic orthostatic hypotension; hypothesis-generating and requires prospective validation.
Orthostatic hypotension is a common cause of syncope, especially in the older adult population. While it is a commonly encountered issue as a cause of syncope, neurogenic orthostatic hypotension (nOH) is less common. Accurate diagnosis and management of neurogenic orthostatic hypotension is important especially when conservative measures fail. The condition of nOH is often seen in Parkinson disease or Parkinson plus syndromes. We present an unusual presentation of a patient with nOH who had no parkinsonian features but once started on norepinephrine agonism improved dramatically.
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Yavuz et al. (2024) conducted a case report in Neurogenic orthostatic hypotension (n=1). Norepinephrine agonism was evaluated on Clinical improvement. Norepinephrine agonism dramatically improved symptoms in a patient with neurogenic orthostatic hypotension lacking typical parkinsonian features.
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