A promising synthetic route towards bioactive guaianolide sesquiterpene lactones is presented. The strategy is based on a recently invented multicomponent reaction (MARDi cascade) and subsequent highly chemoselective and domino transformations for the expeditious stereoselective preparation of the tricyclic core of the natural products. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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Reboul et al. (2008) studied this question.
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