Key result
A 44mer RNA from the EMCV IRES, containing distinct 15mer and 11mer stem loop motifs, was identified as a potential building block for designing RNA nanostructures for medical applications.
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Identified conserved RNA motifs from EMCV IRES that could serve as building blocks for RNA nanostructures in medical applications.
The highly conserved secondary structural RNA motifs endowed by the IRES element of EMCV picornavirus provide an excellent platform to design RNA nanostructures for application in medicine. We have identified a 44mer RNA, hosting distinct 15mer and 11mer RNA stem loop motifs, as potential building blocks for the design of RNA nanostructures.
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Chan et al. (2012) studied this question. A 44mer RNA from the EMCV IRES, containing distinct 15mer and 11mer stem loop motifs, was identified as a potential building block for designing RNA nanostructures for medical applications.
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