Key result
Smoking amplifies the positive association between BMI and coronary heart disease, with a 2 kg/m2 higher BMI increasing CHD risk by 13% (HR 1.13) in current smokers compared to 9% (HR 1.09) in non-smokers.
Why the study?
Does cigarette smoking amplify the association between body mass index and coronary heart disease or stroke in individuals in the Asia Pacific region?
Population
378,579 individuals from 38 cohorts in the Asia Pacific region
Comparison
Higher Body Mass Index (BMI) in current smokers vs Higher Body Mass Index (BMI) in non-smokers
Design
Meta-analysis
Follow-up
mean 3.8 years
Loading...
Supports combined smoking cessation and weight management; extends BMI-CHD interaction evidence to Asia-Pacific cohorts.
Meta-Analysis (n=378,579)
Yes
Does cigarette smoking amplify the association between body mass index and coronary heart disease or stroke in individuals in the Asia Pacific region?
Hazard Ratio: 1.13 (95% CI 1.1–1.17)
p-value: p=0.04
Cigarette smoking synergistically amplifies the risk of coronary heart disease associated with higher body mass index, highlighting the importance of combined smoking cessation and weight loss strategies.
A 2009 study conducted a meta-analysis in Coronary heart disease and stroke (n=378,579). Cigarette smoking and Body Mass Index (BMI) vs. Non-smokers was evaluated on Coronary heart disease (CHD) associated with a 2 kg/m2 higher BMI (HR 1.13, 95% CI 1.10-1.17, p=0.04). Smoking amplifies the positive association between BMI and coronary heart disease, with a 2 kg/m2 higher BMI increasing CHD risk by 13% (HR 1.13) in current smokers compared to 9% (HR 1.09) in non-smokers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: