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Easy does it: A wide range of N-fused indole skeletons, which are core structures of many biologically potent molecules, are successfully furnished by a niobium-catalyzed C(sp3)H insertion reaction (see picture). The precursors are readily prepared by a palladium-catalyzed amination reaction of bromotrifluorotoluenes with cyclic amines.
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Fuchibe et al. (2009) studied this question.
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