Key result
Noradrenaline (10-100 microM) caused a 93-100% inhibition of the fast excitatory postsynaptic potential in guinea-pig gall-bladder ganglia via alpha 2-adrenoreceptors.
Population
guinea-pig gall-bladder ganglia
Design
Preclinical
Authors
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Alpha2-mediated presynaptic inhibition may modulate gallbladder ganglionic transmission; leaves open translation to human biliary physiology.
Noradrenaline exerts an alpha 2-adrenoreceptor-mediated presynaptic inhibitory effect on fast synaptic transmission in guinea-pig gall-bladder ganglia.
Gary M. Mawe (1993) studied this question. Noradrenaline was evaluated on Amplitude of the fast excitatory postsynaptic potential (EPSP). Noradrenaline (10-100 microM) caused a 93-100% inhibition of the fast excitatory postsynaptic potential in guinea-pig gall-bladder ganglia via alpha 2-adrenoreceptors.
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