Why the study?
The maternal-fetal relationship is increasingly viewed as a unified, adaptive, and multiscale network rather than an interaction between separate entities, prompting a synthesis to map this communicatome.
Design
Scoping review
Key result
The maternal-fetal relationship functions as a unified physiological network where decoupling of autonomic and molecular interactions serves as an early-warning marker for pregnancy pathologies.
Authors
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May support biosignal monitoring for early detection of pre-eclampsia and FGR; extends network physiology framework to maternal-fetal dyad.
The decoupling of the maternal-fetal physiological network, detectable through integrated biosignal analysis such as heart rate variability coupling, serves as a critical early-warning marker for pregnancy pathologies and neurodevelopmental vulnerabilities.
Igor V. Lakhno (2026) conducted a review in Pregnancy (n=38). Maternal-fetal network physiology interactions vs. Decoupled network interactions was evaluated. The maternal-fetal relationship functions as a unified physiological network where decoupling of autonomic and molecular interactions serves as an early-warning marker for pregnancy pathologies.