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September 10, 2026Biomedical Chromatography

Simultaneous Determination of Three Residual Monomers in Polyvinyl Alcohol Eye Drops Using a Dual‐Wavelength RP‐HPLC Method and Evaluation of Its Greenness

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Authors

YZYang ZeyanGWGao WenfenZLZhiyuan Li

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Overview

Methodological study demonstrates sensitive dual-wavelength HPLC detection of residual monomers in polyvinyl alcohol eye drops, indicating an eco-friendly approach to ophthalmic quality control.

Key Points

  • Develop and validate an environmentally sustainable dual-wavelength RP-HPLC method to simultaneously quantify three residual monomers in polyvinyl alcohol eye drops.
  • Separated 2-pyrrolidone, N-vinyl-2-pyrrolidone, and vinyl acetate on a NanoChrom 300 C18 column using an isocratic mobile phase of water, methanol, and acetonitrile (90:5:5, v/v/v).
  • Monitored analyte absorbance using dual ultraviolet wavelengths at 205 nm and 235 nm.
  • Assessed method sustainability using the Analytical Eco-Scale, Analytical Method Greenness Score (AMGS), and Modified Green Analytical Procedure Index (MoGAPI).
  • Achieved simultaneous chromatographic resolution and quantitative determination of all three target residual monomers in polyvinyl alcohol eye drop formulations.
  • Demonstrated satisfactory sensitivity, accuracy, and precision suitable for routine pharmaceutical quality control of povidone-containing ophthalmic formulations.
  • Confirmed high environmental sustainability and operational greenness across all three standardized assessment tools.

Cite This Study

Zeyan et al. (2026) studied this question.

synapsesocial.com/papers/6aa27a9f58559d80afc7358ehttps://doi.org/10.1002/bmc.70613
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