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Meta-analysis reveals consistent clinical outcomes for preloaded Descemet membrane endothelial keratoplasty in corneal transplant recipients, suggesting improved surgical efficiency and adoption.
Preloaded Descemet membrane endothelial keratoplasty (pl-DMEK) involves ready-to-use eye-bank validated tissues. Clinical studies have demonstrated postoperative outcomes comparable to surgeon-prepared tissues, with endothelium-in (endo-in) and endothelium-out (endo-out) configurations [ 1 ]. pl-DMEK improves procedural standardization, surgical efficiency, and tissue utilization while lowering technical barriers to DMEK adoption [ 2 , 3 ]. This meta-analysis consolidated clinical outcomes of pl-DMEK with endo-in and endo-out.
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Romano et al. (2026) studied this question.
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