What does this research mean for the field?

Kidney transplant recipients have a fracture risk comparable to that of waitlisted dialysis patients, and these fractures are not significantly associated with increased mortality in either group. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare the incidence of fractures between kidney transplant recipients and waitlisted dialysis patients and determine whether fracture events are associated with all-cause mortality in each cohort.

September 10, 2026Clinical Nephrology

Fracture incidence and mortality in kidney transplant recipients compared with waitlisted dialysis patients: A single-center retrospective analysis

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Authors

JLJae Sung Lee MNMinji Noh EPEun Hee Park

Discussion

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Overview

Retrospective cohort study observes similar fracture incidence between kidney transplant recipients and dialysis patients, indicating that transplantation alone does not resolve bone fragility.

Key Points

To compare the incidence of fractures between kidney transplant recipients and waitlisted dialysis patients and determine whether fracture events are associated with all-cause mortality in each cohort.
Conducted a retrospective single-center cohort study evaluating 504 kidney transplant recipients and 423 waitlisted dialysis patients at a tertiary hospital in South Korea from 1998 to 2019.
Identified fracture events through radiological report reviews and extracted mortality data from patient medical records.
Applied multivariate Cox proportional hazards regression models to evaluate predictors of mortality, incorporating fracture occurrence and immunosuppressive agents as covariates.
Fracture incidence did not differ significantly between kidney transplant recipients (9.1%) and waitlisted dialysis patients (12.5%).
Fractures were not significantly associated with all-cause mortality in kidney transplant recipients (HR, 2.03; 95% CI, 0.62–6.67; p = 0.24) or dialysis patients (HR, 0.97; 95% CI, 0.12–8.08; p = 0.98).
Age served as the strongest mortality predictor, whereas tacrolimus use was associated with significantly reduced mortality compared to cyclosporine among transplant recipients (HR, 0.18; 95% CI, 0.05–0.66; p = 0.009).

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/6aa27afb58559d80afc73f91 https://doi.org/10.5414/cn112007

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September 10, 2026Clinical Nephrology

Fracture incidence and mortality in kidney transplant recipients compared with waitlisted dialysis patients: A single-center retrospective analysis

View Full Paper

Ask AI

Bookmark

Authors

JLJae Sung Lee MNMinji Noh EPEun Hee Park

Discussion

Member takes

Overview

Retrospective cohort study observes similar fracture incidence between kidney transplant recipients and dialysis patients, indicating that transplantation alone does not resolve bone fragility.

Key Points

To compare the incidence of fractures between kidney transplant recipients and waitlisted dialysis patients and determine whether fracture events are associated with all-cause mortality in each cohort.
Conducted a retrospective single-center cohort study evaluating 504 kidney transplant recipients and 423 waitlisted dialysis patients at a tertiary hospital in South Korea from 1998 to 2019.
Identified fracture events through radiological report reviews and extracted mortality data from patient medical records.
Applied multivariate Cox proportional hazards regression models to evaluate predictors of mortality, incorporating fracture occurrence and immunosuppressive agents as covariates.
Fracture incidence did not differ significantly between kidney transplant recipients (9.1%) and waitlisted dialysis patients (12.5%).
Fractures were not significantly associated with all-cause mortality in kidney transplant recipients (HR, 2.03; 95% CI, 0.62–6.67; p = 0.24) or dialysis patients (HR, 0.97; 95% CI, 0.12–8.08; p = 0.98).
Age served as the strongest mortality predictor, whereas tacrolimus use was associated with significantly reduced mortality compared to cyclosporine among transplant recipients (HR, 0.18; 95% CI, 0.05–0.66; p = 0.009).

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/6aa27afb58559d80afc73f91 https://doi.org/10.5414/cn112007

View Full Paper

Ask AI

Bookmark