Comparison of the Bioaccessibility of Two Formulations of Magnesium Bisglycinate Using an In Vitro Simulation of the Upper Gastrointestinal Tract

Cindy Duysburgh; Marlies Govaert; Peter Azmi; Robert Finn; Nylen Simmons; Massimo Marzorati

doi:10.1080/19390211.2026.2727023

September 8, 2026Journal of Dietary Supplements

Comparison of the Bioaccessibility of Two Formulations of Magnesium Bisglycinate Using an In Vitro Simulation of the Upper Gastrointestinal Tract

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Key Points

To determine whether different formulations of the identical salt, magnesium bisglycinate, alter magnesium release efficiency and passive diffusion in simulated human intestinal conditions.
Simulated human upper gastrointestinal tract digestion using an in vitro model.
Tested two distinct physical or chemical formulations of magnesium bisglycinate.
Measured magnesium release kinetics and passive diffusion capacity in the small intestine phase.
Demonstrates that formulation design alters the rate and extent of magnesium release from identical magnesium bisglycinate salts.
Identifies differences in passive diffusion efficiency across simulated intestinal barriers between the two tested preparations.

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Implication

In vitro simulation evaluates magnesium release and diffusion across formulations, indicating delivery matrices impact gastrointestinal mineral bioaccessibility.

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Duysburgh et al. (2026) studied this question.

synapsesocial.com/papers/6aa27b3558559d80afc743f3 https://doi.org/10.1080/19390211.2026.2727023

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Comparison of the Bioaccessibility of Two Formulations of Magnesium Bisglycinate Using an In Vitro Simulation of the Upper Gastrointestinal Tract

Key Points

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Implication

Discussion

Cite This Study

Comparison of the Bioaccessibility of Two Formulations of Magnesium Bisglycinate Using an In Vitro Simulation of the Upper Gastrointestinal Tract

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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