What does this research mean for the field?

Collisional activation in QToF-TWIMS instruments provides an efficient method to probe gas-phase isomerization kinetics, though the system-dependent nature of pre-activation ion temperatures currently prevents a universal temperature calibration. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate collision-induced isomerization kinetics and derive internal energy distribution parameters of stereoisomeric azobenzene ions using ion mobility mass spectrometry.

September 10, 2026Journal of the American Society for Mass Spectrometry

Kinetics of Collision-Induced Back-Isomerization of Photoisomer Ions

View Full Paper

Ask AI

Bookmark

Authors

TRThomas RobertUniversity of Mons GHGwendal HenrardUniversity of Mons BTBenjamin TassignonUniversity of Mons

Discussion

Member takes

Implication

Spectrometric analysis demonstrates collision-induced back-isomerization in azobenzene-bearing peptoids, revealing system-dependent pre-activation temperatures that limit universal calibration.

Key Points

To evaluate collision-induced isomerization kinetics and derive internal energy distribution parameters of stereoisomeric azobenzene ions using ion mobility mass spectrometry.
Interrogated sequence-defined peptoids bearing an azobenzene chromophore using traveling wave-ion mobility spectrometry on a quadrupole time-of-flight platform.
Tracked collision-induced Z-to-E back-isomerization as a function of Trap Cell activation voltage to derive kinetic rate constants from ion residence times.
Integrated activation parameters into a modified Eyring framework to extract kinetic-to-internal energy conversion efficiency (α) and pre-activation temperature (T0).
Trap activation voltage reliably drove Z-to-E photoisomer conversion, allowing the determination of effective internal temperatures across the ion population.
Energy conversion efficiency (α) values aligned closely with previously reported values obtained from protein ions.
Pre-activation ion population temperatures (T0) varied across individual molecular systems, demonstrating a structural dependence that precludes a universal temperature calibration curve.

Cite This Study

Robert et al. (2026) studied this question.

synapsesocial.com/papers/6aa27b3558559d80afc7451d https://doi.org/10.1021/jasms.6c00196

View Full Paper

Ask AI

Bookmark

Implication

Spectrometric analysis demonstrates collision-induced back-isomerization in azobenzene-bearing peptoids, revealing system-dependent pre-activation temperatures that limit universal calibration.

Kinetics of Collision-Induced Back-Isomerization of Photoisomer Ions

Discussion

Member takes

Implication

Key Points

Cite This Study

Kinetics of Collision-Induced Back-Isomerization of Photoisomer Ions

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider