What does this research mean for the field?

The novel Fetal Embolization via Transcardiac, Transarterial, Ultrasound- and fluoroscopy-guided endovascular Surgery (FETTUS) technique is a feasible approach for performing in utero neuroendovascular embolization, allowing successful target embolization and fetal survival in a lamb model. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

Evaluate the feasibility, procedural workflow, and technical refinement of FETTUS, a novel ultrasound- and fluoroscopy-guided transcardiac embolization procedure for vein of Galen malformation.

September 10, 2026Journal of NeuroInterventional Surgery

Technical note on FETTUS: a novel transcardiac ultrasound- and fluoroscopy-guided fetal embolization technique for vein of Galen malformation in fetal lambs

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Authors

KCKaren Chen MBMichael Belfort TKTimo Krings

Discussion

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Overview

Preclinical study demonstrates successful transcardiac endovascular embolization in fetal lambs, indicating feasibility for prenatal intervention in vein of Galen malformation.

Key Points

Evaluate the feasibility, procedural workflow, and technical refinement of FETTUS, a novel ultrasound- and fluoroscopy-guided transcardiac embolization procedure for vein of Galen malformation.
Developed and evaluated the FETTUS technique across fetal lambs (N=17) equivalent to human gestational ages of 26 to 34 weeks.
Used combined transcardiac ultrasound and fluoroscopy guidance to obtain left ventricular access, visualize head and neck vasculature, and perform endovascular embolization.
Procedural efficiency improved across cohorts, resulting in decreased time required for successful left ventricular access.
Iterative technical refinements enabled reliable angiographic navigation and target embolization with preserved fetal survival.
Cumulative radiation exposure and contrast volumes consistently remained below clinically acceptable safety thresholds.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6aa27b4758559d80afc745ff https://doi.org/10.1136/jnis-2026-025580

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September 10, 2026Journal of NeuroInterventional Surgery

Technical note on FETTUS: a novel transcardiac ultrasound- and fluoroscopy-guided fetal embolization technique for vein of Galen malformation in fetal lambs

View Full Paper

Ask AI

Bookmark

Authors

KCKaren Chen MBMichael Belfort TKTimo Krings

Discussion

Member takes

Overview

Preclinical study demonstrates successful transcardiac endovascular embolization in fetal lambs, indicating feasibility for prenatal intervention in vein of Galen malformation.

Key Points

Evaluate the feasibility, procedural workflow, and technical refinement of FETTUS, a novel ultrasound- and fluoroscopy-guided transcardiac embolization procedure for vein of Galen malformation.
Developed and evaluated the FETTUS technique across fetal lambs (N=17) equivalent to human gestational ages of 26 to 34 weeks.
Used combined transcardiac ultrasound and fluoroscopy guidance to obtain left ventricular access, visualize head and neck vasculature, and perform endovascular embolization.
Procedural efficiency improved across cohorts, resulting in decreased time required for successful left ventricular access.
Iterative technical refinements enabled reliable angiographic navigation and target embolization with preserved fetal survival.
Cumulative radiation exposure and contrast volumes consistently remained below clinically acceptable safety thresholds.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6aa27b4758559d80afc745ff https://doi.org/10.1136/jnis-2026-025580

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