Key result
Novel reassortant IBDV strain IBDV_G3 from quails carries A0 and B1a lineages and replicates efficiently.
Why the study?
Infectious bursal disease virus triggers severe immunosuppression in birds and causes substantial economic losses to the poultry industry globally.
Quails may harbor reassortant IBDV strains, highlighting the need for continuous surveillance at the quail-chicken interface for evolutionary variation.
Quails may harbor reassortant IBDV strains; leaves open the need for surveillance studies at poultry interfaces.
Infectious bursal disease virus (IBDV) primarily triggers severe immunosuppression in birds and has resulted in substantial economic losses to the poultry industry globally. Here, a novel naturally reassortant IBDV strain, designated IBDV_G3, was isolated from quails during a disease outbreak in Jiangsu Province, China. Genome sequencing revealed that IBDV_G3 carried segment A derived from the serotype-2-related A0 lineage, while segment B clustered within the B1a classical-like lineage, and this genomic constellation was further confirmed in the original uncultured quail tissues. IBDV_G3 replicated efficiently in LMH cells without prior adaptation, and its VP2 was recognized by the serotype 1 VP2-specific monoclonal antibody 5G10. These findings suggest that quails may harbor reassortant IBDV strains and that the quail–chicken interface warrants continuous surveillance for IBDV reassortment and evolutionary variation.
No takes yet. Share an insight, caveat, or question.
Guo et al. (2026) studied Infectious bursal disease virus (IBDV) infection. Genomic sequencing and characterization was evaluated on Genomic constellation and in vitro replication. A novel naturally reassortant IBDV strain, IBDV_G3, was isolated from quails, carrying segment A from the A0 lineage and segment B from the B1a lineage, and replicated efficiently in LMH cells.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: