Key result
DCB angioplasty with factor VIII and short DAPT yields 0 events in hemophilia A with AMI.
Why the study?
Hemophilia A combined with acute myocardial infarction is rare and clinically challenging to treat.
Case Report (n=1)
Drug-coated balloon angioplasty with a shortened 3-week DAPT course may be a safe and effective strategy for managing acute myocardial infarction in patients with hemophilia A.
May support individualized DCB strategies with abbreviated DAPT in hemophilia A AMI; leaves open prospective validation before practice change.
Hemophilia A combined with acute myocardial infarction (AMI) is rare and challenging to treat. This article reports a 65-year-old patient with hemophilia A admitted for acute inferior ST-segment elevation myocardial infarction, who successfully underwent emergency drug-coated balloon (DCB) angioplasty with factor VIII replacement support. Dual antiplatelet therapy (DAPT) was discontinued 3 weeks after the operation, after which the patient received neither antithrombotic therapy nor replacement therapy, while comprehensive risk factor control was intensified. No recurrent thrombotic or hemorrhagic events were observed during the 1-year follow-up. This case suggests that the DCB strategy can shorten the required duration of antithrombotic treatment, and discontinuing antithrombotic and replacement therapies may be safe for selected patients, with comprehensive risk factor control serving as the core antithrombotic intervention at this stage.
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Huang et al. (2026) conducted a case report in Hemophilia A combined with acute myocardial infarction (AMI) (n=1). Emergency drug-coated balloon (DCB) angioplasty with factor VIII replacement support was evaluated on Recurrent thrombotic or hemorrhagic events. Emergency drug-coated balloon angioplasty with factor VIII replacement and 3 weeks of DAPT resulted in no recurrent thrombotic or hemorrhagic events at 1 year in a patient with hemophilia A and AMI.
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